Product Name :
2-Hydroxysaclofen (CAS 117354-64-0)
Synonym :
(RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Application :
2-Hydroxysaclofen is a selective GABAB antagonist
CAS:
117354-64-0
Purity:
Molecular Weight:
265.71
Formula :
C9H12ClNO4S
Physical state:
Solid
solubility :
Soluble in 0.1 M NaOH (9.5 mg/mL), water (1 mg/mL), methanol (1.4 mg/mL), and DMSO (28 mg/mL).
Shipping Condition :
Store at room temperature
Melting point:
SMILES:
C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl
References:
:2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. | Akema, T. and Kimura, F. 1991. Brain Res. 546: 143-5. PMID: 1649666Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats. | Saigusa, T., et al. 2008. Eur J Pharmacol. 581: 276-82. PMID: 18206140The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. | Miranda, F., et al. 2009. Pharmacol Biochem Behav. 93: 25-30. PMID: 19361543Effect of 2-hydroxy-saclofen, an antagonist of GABAB action, upon the binding of baclofen and other receptor ligands in rat cerebrum.2436296-66-9 uses | al-Dahan, MI.N-Desethyl amodiaquine dihydrochloride web , et al. 1990. Brain Res. 526: 308-12. PMID: 2175242Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice. | Bonaventura, MM., et al. 2012. Eur J Pharmacol. 677: 188-96. PMID: 22210053Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. | Varani, AP., et al. 2014. Eur J Pharmacol. 738: 200-5. PMID: 24886886Nicotine-induced molecular alterations are modulated by GABAB receptor activity.PMID:33387155 | Varani, AP., et al. 2018. Addict Biol. 23: 230-246. PMID: 284196422-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors. | Kerr, DI., et al. 1988. Neurosci Lett. 92: 92-6. PMID: 2847092Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord. | Curtis, DR., et al. 1988. Neurosci Lett. 92: 97-101. PMID: 2847093Participation of GABAB Receptors of Parafacial Respiratory Group in the Regulation of Respiration in Rats. | Kovaleva, TE. and Vedyasova, OA. 2019. Bull Exp Biol Med. 168: 24-27. PMID: 317456832-Hydroxy-saclofen causes a phaclofen-reversible reduction in population spike amplitude in the rat hippocampal slice. | Caddick, SJ., et al. 1995. Eur J Pharmacol. 274: 41-6. PMID: 7768279Supraspinal delta 2 opioid agonist analgesia in Swiss-Webster mice involves spinal GABAA receptors. | Rady, JJ. and Fujimoto, JM. 1996. Pharmacol Biochem Behav. 54: 363-9. PMID: 8743596The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations. | Kerr, DI., et al. 1995. Eur J Pharmacol. 287: 185-9. PMID: 8749034