Product Name :
2-Chloro-2′-deoxyadenosine (CAS 4291-63-8)
Synonym :
Cladribine; 2CdA
Application :
2-Chloro-2′-deoxyadenosine is an apoptosis inducer
CAS:
4291-63-8
Purity:
≥99%
Molecular Weight:
285.7
Formula :
C10H12ClN5O3
Physical state:
Solid
solubility :
Soluble in DMSO ( ≥57 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), and methanol.BuyDSG Crosslinker
Shipping Condition :
Store at 4° C
Melting point:
181-185° C (lit.)
SMILES:
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
References:
:Cladribine activity in systemic mast cell disease: application of biochemistry in the modern era of molecular biology.2-(Tributylstannyl)thiophene custom synthesis | Nieva, J. and Saven, A. 2004. Leuk Res. 28: 113-4. PMID: 14654073[Synthesis of 2-chloro-2′-deoxyadenosine by microbiological transglycosylation using a recombinant Escherichia coli strain]. | Taran, SA., et al. 2008. Prikl Biokhim Mikrobiol. 44: 181-6. PMID: 18669260Beyond hairy cell: the activity of cladribine in other hematologic malignancies. | Sigal, DS., et al. 2010. Blood. 116: 2884-96. PMID: 20634380Cladribine: mode of action and implications for treatment of multiple sclerosis. | Leist, TP. and Weissert, R. 2011. Clin Neuropharmacol. 34: 28-35. PMID: 21242742Potential mechanisms of action related to the efficacy and safety of cladribine. | Baker, D., et al. 2019. Mult Scler Relat Disord. 30: 176-186. PMID: 30785074Adenosine Signaling in Glioma Cells. | Ceruti, S. and Abbracchio, MP. 2020. Adv Exp Med Biol. 1202: 13-33. PMID: 32034707The development and impact of cladribine on lymphoid and myeloid cells in multiple sclerosis. | Voo, VTF., et al. 2021. Mult Scler Relat Disord. 52: 102962. PMID: 33901971B cells in multiple sclerosis – from targeted depletion to immune reconstitution therapies. | Cencioni, MT., et al. 2021. Nat Rev Neurol.PMID:33709227 17: 399-414. PMID: 34075251Reviewing the Significance of Blood-Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment. | Balasa, R., et al. 2021. Int J Mol Sci. 22: PMID: 34445097Erdheim-Chester disease. | Brychtová, M., et al. 2021. Klin Onkol. 34: 434-439. PMID: 34911328Mass cytometry reveals cladribine-induced resets among innate lymphoid cells in multiple sclerosis. | Aglas-Leitner, FT., et al. 2022. Sci Rep. 12: 20411. PMID: 36437270Cladribine for the treatment of hematologic malignancies. | Baltz, JK. and Montello, MJ. 1993. Clin Pharm. 12: 805-13; quiz 860-2. PMID: 7903917Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. | Górski, A., et al. 1993. Immunopharmacology. 26: 197-202. PMID: 7904595