Ipt; offered in PMC 2014 June 01.Chlebowski et al.PageStudy strengths contain the size of your significant properly characterized, ethnically diverse study population, serial joint symptom determination within the context of a randomized clinical trial using a quantitative instrument which was prospectively applied. However, joint symptoms had been not major study endpoints and the findings emerge from post hoc analyses. Also, the joint pain and joint swelling scales applied have not been in comparison to other instruments or formally validated.NIHPA Author Manuscript NIHPA Author Manuscript NIHPA Author ManuscriptConclusionCurrent study findings suggest that estrogen alone use in postmenopausal ladies with prior hysterectomy benefits within a modest but sustained and statistically considerable reduction in joint pain.AcknowledgmentsRole on the Sponsor: The Women’s Health Institute (WHI) Project Workplace in the National Heart, Lung, and Blood Institute (NHLBI), the Sponsor, reviewed and authorized the final manuscript but had no other part in the preparation of this report. Decisions regarding study style, information collection and analysis, interpretation with the final results, the preparation on the manuscript, or the selection to submit the manuscript for publication resided with committees comprised of WHI investigators that incorporated NHLBI representatives. WHI INVESTIGATORS Plan Office: (National Heart, Lung, and Blood Institute, Bethesda, Maryland) Barbara Alving, Jacques Rossouw, Linda Pottern, Shari Ludlam, Joan McGowan, Nancy Geller, Leslie Ford. Clinical Coordinating Center: (Fred Hutchinson Cancer Investigation Center, Seattle, WA) Ross Prentice, Garnet Anderson, Andrea LaCroix, Ruth Patterson, Anne McTiernan, Barbara Cochrane, Julie Hunt, Lesley Tinker, Charles Kooperberg, Martin McIntosh, C. Y. Wang, Chu Chen, Deborah Bowen, Alan Kristal, Janet Stanford, Nicole Urban, Noel Weiss, Emily White; (Wake Forest University College of Medicine, WinstonSalem, NC) Sally Shumaker, Ronald Prineas, Michelle Naughton; (Health-related Study Laboratories, Highland Heights, KY) Evan Stein, Peter Laskarzewski; (San Francisco Coordinating Center, San Francisco, CA) Steven R.4-(Difluoromethyl)-3-fluorobenzoic acid In stock Cummings, Michael Nevitt, Lisa Palermo; (University of Minnesota, Minneapolis, MN) Lisa Harnack; (Fisher BioServices, Rockville, MD) Frank Cammarata, Steve Lindenfelser; (University of Washington, Seattle, WA) Bruce Psaty, Susan Heckbert.Fmoc-Ala-OH Data Sheet Clinical Centers: (Albert Einstein College of Medicine, Bronx, NY) Sylvia WassertheilSmoller, William Frishman, Judith WylieRosett, David Barad, Ruth Freeman; (Baylor College of Medicine, Houston, TX) Jennifer Hays, Ronald Young, Jill Anderson, Sandy Lithgow, Paul Bray; (Brigham and Women’s Hospital, Harvard Healthcare College, Boston, MA) JoAnn Manson, J.PMID:33660564 Michael Gaziano, Claudia Chae, Kathryn Rexrode, Caren Solomon (Brown University, Providence, RI) Annlouise R. Assaf, Carol Wheeler, Charles Eaton, Michelle Cyr; (Emory University, Atlanta, GA) Lawrence Phillips, Margaret Pedersen, Ora Strickland, Margaret Huber, Vivian Porter; (Fred Hutchinson Cancer Research Center, Seattle, WA) Shirley A.A. Beresford, Vicky M. Taylor, Nancy F. Woods, Maureen Henderson, Robyn Andersen; (George Washington University, Washington, DC) Judith Hsia, Nancy Gaba, Joao Ascensao; (HarborUCLA Investigation and Education Institute, Torrance, CA) Rowan Chlebowski, Robert Detrano, Anita Nelson, Michele Geller; (Kaiser Permanente Center for Well being Research, Portland, OR) Evelyn Whitlock, Victor Stevens, Njeri Karanj.