Product Name :
STING Recombinant Rabbit Monoclonal Antibody [PSH07-44]
Predicted band size :
42 kDa
Observed band size :
37 kDa
Synonyms:
endoplasmic reticulum IFN stimulator antibody Endoplasmic reticulum interferon stimulator antibody ERIS antibody FLJ38577 antibody hMITA antibody hSTING antibody Mediator of IRF3 activation antibody MITA antibody Mitochondrial mediator of IRF3 activation antibody MPYS antibody 展开
Function :
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites.Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.330645-87-9 web ) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.3-Bromo-1-naphthoic acid Data Sheet
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human STING aa 117-379.PMID:33554631
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC, IF-Tissue, IP
Coupling :
unconjugated
Clone number:
PSH07-44
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 42 kDa
Positive control :
HDLM-2 cell lysate, THP-1 cell lysate, HT-29 cell lysate, HepG2 cell lysate, HaCaT cell lysate, HL-60 cell lysate, HEK-293 cell lysate, K-562 cell lysate, A20 cell lysate, C2C12 cell lysate, EL4 cell lysate, Rat thymus tissue lysate, human lung tissue, human tonsil tissue, THP-1, PC-12.